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Index > Protein center > PTGS2(Gene name) > Human
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  • PTGS2 (Gene name),
  • Prostaglandin G/H synthase 2 (Protein name ),  PGH2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PTGS2(COX2);
    Protein name:
    Prostaglandin G/H synthase 2;
    Alternative:
    PHS II;Cyclooxygenase-2(COX-2);Prostaglandin-endoperoxide synthase 2;Prostaglandin H2 synthase 2(PGH synthase 2;PGHS-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
    Subcellular Location:
    Microsome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    604
    Sequence:
    50:
    MLARALLLCA | VLALSHTANP | CCSHPCQNRG | VCMSVGFDQY | KCDCTRTGFY | 
    100:
    GENCSTPEFL | TRIKLFLKPT | PNTVHYILTH | FKGFWNVVNN | IPFLRNAIMS | 
    150:
    YVLTSRSHLI | DSPPTYNADY | GYKSWEAFSN | LSYYTRALPP | VPDDCPTPLG | 
    200:
    VKGKKQLPDS | NEIVEKLLLR | RKFIPDPQGS | NMMFAFFAQH | FTHQFFKTDH | 
    250:
    KRGPAFTNGL | GHGVDLNHIY | GETLARQRKL | RLFKDGKMKY | QIIDGEMYPP | 
    300:
    TVKDTQAEMI | YPPQVPEHLR | FAVGQEVFGL | VPGLMMYATI | WLREHNRVCD | 
    350:
    VLKQEHPEWG | DEQLFQTSRL | ILIGETIKIV | IEDYVQHLSG | YHFKLKFDPE | 
    400:
    LLFNKQFQYQ | NRIAAEFNTL | YHWHPLLPDT | FQIHDQKYNY | QQFIYNNSIL | 
    450:
    LEHGITQFVE | SFTRQIAGRV | AGGRNVPPAV | QKVSQASIDQ | SRQMKYQSFN | 
    500:
    EYRKRFMLKP | YESFEELTGE | KEMSAELEAL | YGDIDAVELY | PALLVEKPRP | 
    550:
    DAIFGETMVE | VGAPFSLKGL | MGNVICSPAY | WKPSTFGGEV | GFQIINTASI | 
    600:
    QSLICNNVKG | CPFTSFSVPD | PELIKTVTIN | ASSSRSGLDD | INPTVLLKER | 
    604:
    STEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    SMR:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    E0699h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    E0699r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    ELISA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    E0699b
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    E0699m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    U0699b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    U0699m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    U0699c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    U0699r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prostaglandin G/H synthase 2
    Cat.:
    U0699h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Monoclonal Antibody for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2
    Protein for Human Prostaglandin G/H synthase 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines."
      Jones D.A. , Carlton D.P. , McIntyre T.M. , Zimmerman G.A. , Prescott S.M.
      J. Biol. Chem.268:9049-9054(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Endothelial cell.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Endothelial cell.
    3. 3.
      "Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2."
      Kosaka T. , Miyata A. , Ihara H. , Hara S. , Sugimoto T. , Takeda O. , Takahashi E. , Tanabe T.
      Eur. J. Biochem.221:889-897(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Peripheral blood.
    4. 4.
      "Structure of the human cyclo-oxygenase-2 gene."
      Appleby S.B. , Ristimaki A. , Neilson K. , Narko K. , Hla T.
      Biochem. J.302:723-727(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Sharma S.V. , Aronstam R.S.
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    6. 6.
      NIEHS SNPs program
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-228; ALA-428; ALA-511 AND ARG-587
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Synovium.
    9. 9.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    12. 12.
      "Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system."
      Barnett J. , Chow J. , Ives D. , Chiou M. , Mackenzie R. , Osen E. , Nguyen B. , Tsing S. , Bach C. , Freire J.
      Biochim. Biophys. Acta1209:130-139(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    13. 13.
      "Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2."
      Kim S.F. , Huri D.A. , Snyder S.H.
      Science310:1966-1970(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;S-NITROSYLATION AT CYS-526;MUTAGENESIS OF CYS-526; CYS-555 AND CYS-561
    14. 14.
      "Glycosylation regulates turnover of cyclooxygenase-2."
      Sevigny M.B. , Li C.F. , Alas M. , Hughes-Fulford M.
      FEBS Lett.580:6533-6536(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-580
    15. 15.
      "Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
      Goodman J.E. , Bowman E.D. , Chanock S.J. , Alberg A.J. , Harris C.C.
      Carcinogenesis25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-511
    16. 16.
      "Cyclooxygenases: structural, cellular, and molecular biology."
      Smith W.L. , DeWitt D.L. , Garavito R.M.
      Annu. Rev. Biochem.69:145-182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; TISSUE SPECIFICITY AND INHIBITION BY NSAIDS
    17. 17.
      "Aspirin, cyclooxygenase inhibition and colorectal cancer."
      Sostres C. , Gargallo C.J. , Lanas A.
      World J. Gastrointest. Pharmacol. Ther.5:40-49(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; INHIBITION BY ASPIRIN AND INVOLVEMENT IN COLORECTAL CANCER
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